Risk score accurately predicts which pregnant and postpartum women would benefit most from PrEP

Risk score accurately predicts which pregnant and postpartum women would benefit most from PrEP

By Michael Carter A risk score based on routine assessments carried out during antenatal care in resource-limited settings can accurately predict which pregnant and breastfeeding women have an especially high risk of infection with HIV and would therefore benefit from pre-exposure prophylaxis (PrEP), investigators report in the online edition of Clinical Infectious Diseases. Predictors of infection with HIV included a partner of unknown HIV status, number of lifetime sexual partners, syphilis, bacterial vaginosis and vaginal…

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Negotiating pharmaceutical uncertainty women’s agency in a South African HIV prevention trial

Negotiating pharmaceutical uncertainty women’s agency in a South African HIV prevention trial

  Telling the story of a clinical trial testing an innovative gel designed to prevent women from contracting HIV, Negotiating Pharmaceutical Uncertainty provides new insight into the complex and contradictory relationship between medical researchers and their subjects. Anthropologists, Saethre and Stadler provide a unique and nuanced perspective of the reality of a clinical trial that is often hidden from view. Telling the story of a clinical trial testing an innovative gel designed to prevent women…

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Very high levels of drug resistance seen in patients failing first-line antiretroviral therapy in Kenya

Very high levels of drug resistance seen in patients failing first-line antiretroviral therapy in Kenya

By Gus Cairns Future treatment options severely limited in the quarter who fail therapy A cross-sectional survey of viral load in patients attending the largest clinic providing antiretroviral therapy (ART) in Kenya has shown that after an average of nearly two years on first-line, tenofovir-based ART, 76% maintained a viral load under 40 copies/ml and 85% under 1000 copies/ml, the World Health Organization threshold for significant clinical and transmission consequences. The study also found that…

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