Risk score accurately predicts which pregnant and postpartum women would benefit most from PrEP

Risk score accurately predicts which pregnant and postpartum women would benefit most from PrEP

By Michael Carter A risk score based on routine assessments carried out during antenatal care in resource-limited settings can accurately predict which pregnant and breastfeeding women have an especially high risk of infection with HIV and would therefore benefit from pre-exposure prophylaxis (PrEP), investigators report in the online edition of Clinical Infectious Diseases. Predictors of infection with HIV included a partner of unknown HIV status, number of lifetime sexual partners, syphilis, bacterial vaginosis and vaginal…

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A risk assessment tool for identifying pregnant and postpartum women who may benefit from pre-exposure prophylaxis (PrEP)

Abstract only Jillian Pintye1,2, Alison L. Drake1, John Kinuthia4, Jennifer A. Unger1,3, Daniel Matemo4, Renee Heffron1, Ruanne Barnabas1,5,8, Pamela Kohler1,2, R. Scott McClelland1,5,6,7, and Grace John-Stewart1,5,6,8 Abstract Background: An HIV risk assessment tool for pregnant women could identify women who would most benefit from PrEP while minimizing unnecessary PrEP exposure Methods: Data from a prospective study of incident HIV among pregnant/postpartum women in Kenya was randomly divided into derivation (n=654) and validation (n=650) cohorts. A risk score was derived using multivariate Cox proportional hazards…

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Meeting the needs of urban youth: What does the community say?

Meeting the needs of urban youth: What does the community say?

By Carol Gatura, Communications Officer, APHRC Youth living in urban informal settlements face numerous challenges when it comes to accessing sexual and reproductive health (SRH) information and services. Comprehensive sexuality education is hardly being taught in schools, and parents are not quite sure how to talk about sex with their children. As part of our work on the USAID-funded African Strategies for Health project – a multi-year initiative in collaboration with Management Sciences for Health…

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Very high levels of drug resistance seen in patients failing first-line antiretroviral therapy in Kenya

Very high levels of drug resistance seen in patients failing first-line antiretroviral therapy in Kenya

By Gus Cairns Future treatment options severely limited in the quarter who fail therapy A cross-sectional survey of viral load in patients attending the largest clinic providing antiretroviral therapy (ART) in Kenya has shown that after an average of nearly two years on first-line, tenofovir-based ART, 76% maintained a viral load under 40 copies/ml and 85% under 1000 copies/ml, the World Health Organization threshold for significant clinical and transmission consequences. The study also found that…

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